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Unlike traditional estrogen receptors, ERRs do not bind estrogen but instead share some target genes with estrogen receptors, hence the "estrogen-related" designation

Humectants are able to bind and hold large amounts of water to keep skin hydrated

Animal studies indicate a plasma half-life of approximately 1-2 hours, with rapid tissue distribution facilitating its role in wound contraction and epithelialization

The regulation of diverse transcription factors, receptors for growth factors (including FGFR2b, FGFR2c, EGFR and HER2), and the activation of Akt are other elements in the reversion of MET [24]

Regardless of these limitations, the results of this review provide valuable insights regarding ivermectin mechanisms that have been identified in relevant ectoparasites in previous research and may inform future research and resistance monitoring strategies